| Airline Name | ICAO | IATA | Callsign | Country |
| EA-727 | United States | |||
| Eagle Air | ISL | Iceland | ||
| Eagle Airlines | United States | |||
| Eagle Aviation | EQA | Y4 | MAGNUM | Kenya |
| Eagle Aviation France | EGN | FRENCH EAGLE | France | |
| EAL | United States | |||
| Earth Airlines | ERX | EARTH AIR | Nigeria | |
| EAS | United States | |||
| EAS – Europe Aero Service | EYT | EY | EURO LINE | France |
| EAS Airlines | EXW | Nigeria | ||
| East African Airways | EC | Multinational | ||
| East African Safari Air | HSA | S9 | Kenya | |
| East Air | ETJ | EAST TAJIK | Tajikistan | |
| East Airways | United States | |||
| East Star Airlines | DXH | 8C | EAST STAR | China |
| East West Airlines | India | |||
| East-West Airlines | EWA | EW | Australia | |
| Eastar Jet | ESR | ZE | EASTAR | Korea, Republic Of |
| Eastern Airlines | EAL | EA | United States | |
| Eastern Airways | EZE | T3 | EASTFLIGHT | United Kingdom |
| Eastern Australia Airlines | EAQ | EASTERN | Australia | |
| Eastern Provincial | EPA | PV | Canada | |
| Eastern Skyjets | United Arab Emirates | |||
| Eastindo | Indonesia | |||
| Eastok Avia | EAA | EASTOK | Kyrgyzstan | |
| Eastwind Airlines | SGR | W9 | United States | |
| Easy Aviation | Austria | |||
| Easyjet | EZY | U2 | EASY | United Kingdom |
| Easyjet Switzerland | EZS | DS | TOPSWISS | Switzerland |
| EBA France | France | |||
| EBA Italy | Italy | |||
| EC Xpress | JM | Jamaica | ||
| Ecoair International | DEI | 9H | Algeria | |
| Ecuato Guineana de Aviacion | ECV | Equatorial Guinea | ||
| Ecuatoriana | EEA | EU | Ecuador | |
| Edelweiss Air | EDW | WK | EDELWEISS | Switzerland |
| Efly | Malta | |||
| Egypt Government | Egypt | |||
| EgyptAir | MSR | MS | EGYPTAIR | Egypt |
| EgyptAir Express | Egypt | |||
| EIE Eagle Inc | United States | |||
| Eirjet | EIR | EIRJET | Ireland | |
| El Al Israel Airlines | ELY | LY | Israel | |
| El Sol de America | ESC | SOLAMERICA | Venezuela | |
| Elders IXL | United States | |||
| Electra Airlines | ELD | Greece | ||
| Embraer | Brazil | |||
| Emerald Airways | JEM | United Kingdom | ||
| Emery Worldwide Airlines | EWW | EB | United States | |
| Emirates | UAE | EK | EMIRATES | United Arab Emirates |
| Empire Airlines | CFS | EM | United States | |
| Empost | United Arab Emirates | |||
| Enerjet | Canada | |||
| Enimex | ENI | Estonia | ||
| Eos Airlines | EES | E0 | NEW DAWN | United States |
| Equatorial Guinea Government | Equatorial Guinea | |||
| ERA Aviation | ERH | 7H | United States | |
| ERA European Regions Airlines | EUA | EA | Spain | |
| Eram Air | IRY | YE | ERAM AIR | Iran, Islamic Republic Of |
| Eritrean Airlines | ERT | B8 | Eritrea | |
| Ernest Angley Ministries | United States | |||
| Esen Air | ESD | ESEN AIR | Kyrgyzstan | |
| Esso Resources Canada | ERC | Canada | ||
| Estafeta Carga Aerea | Mexico | |||
| Estelar Latinoamerica | Venezuela | |||
| Estonian Air | ELL | OV | Estonia | |
| Ethiopian Airlines | ETH | ET | Ethiopia | |
| Etihad Airways | ETD | EY | ETIHAD | United Arab Emirates |
| EUjet | EUJ | VE | UNION JET | Ireland |
| Euralair International | ERL | RN | EURALAIR EXECUTIVE | France |
| Eureca | URE | F4 | Italy | |
| Euro Continental Air | ECN | Spain | ||
| Euro Direct Airlines | 9R | United Kingdom | ||
| Euro First Air | EFA | Spain | ||
| Euro Sun | ESN | Turkey | ||
| Euro-Hopper | DNM | 3D | Germany | |
| EuroAir | EUP | 6M | EUROSTAR | Greece |
| EuroAtlantic Airways | MMZ | MM | Portugal | |
| EuroBelgian Airlines | EBA | BQ | Belgium | |
| Euroberlin | EEB | EE | France | |
| Euroceltic Airways | ECY | 5Q | United Kingdom | |
| Eurocypria Airlines | ECA | UI | Cyprus | |
| Eurofly | EEZ | GJ | E-FLY | Italy |
| Euroguineana de Aviacion | EUG | Equatorial Guinea | ||
| Eurojet Airlines | France | |||
| EuroLine | MJX | 4L | Georgia | |
| Eurolink (SAS Commuter) | SAS | SK | SCANDINAVIAN | Denmark |
| Eurolot | ELO | K2 | Poland | |
| Eurolynx Aviation | United Kingdom | |||
| Euromanx | EMX | 3W | EUROMANX | United Kingdom |
| EuroMediterranean Airlines | Egypt | |||
| Europe Airpost | FPO | France | ||
| European Air Express | EAE | EA | STARWING | Germany |
| European Air Transport | BCS | QY | Belgium | |
| European Aircharter | EAF | E7 | EUROCHARTER | United Kingdom |
| European Airlift | Belgium | |||
| European Airlines | FRO | Belgium | ||
| European Aviation Air Charter | EAF | E7 | United Kingdom | |
| Euroscot Airways | EUJ | MY | United Kingdom | |
| Eurowings | EWG | EW | Germany | |
| EVA Airways | EVA | BR | EVA | Taiwan |
| Evergreen International Airlines | EIA | EZ | United States | |
| Excalibur Airways | EXC | EQ | United Kingdom | |
| Excel Airways | XLA | JN | United Kingdom | |
| Excellence | United States | |||
| Excellent Air | GZA | Germany | ||
| Execujet Flight Operations | EOP | South Africa | ||
| Executive Aero Space | EAS | South Africa | ||
| Executive Air Charter | Puerto Rico | |||
| Executive Airlines (American Eagle) | EXK | OW | EXECUTIVE EAGLE | Puerto Rico |
| Executive Jet Management | EJM | United States | ||
| Executive Turbine Aviation | TEA | TRAVELMAX | South Africa | |
| Express City | EO | The Democratic Republic Of The Congo | ||
| Express One International | LHN | EO | United States | |
| Express.Net Airlines | XNA | United States | ||
| ExpressJet Airlines | BTA | XE | JET LINK | United States |